Harp Oketsky’s farm in dust-drowned Uz, Nebraska, is flourishing even as his neighbors’ are failing. And a serial killer is on the loose, even if the town sheriff tries to bury the plot. Central to the story though is a “prairie witch,” the antidote in the title, whose strength as a keeper of secrets might be on the wane. Russell is famous for elements of magical realism and this novel too weaves strands in expertly. At times the stories of the various characters strain to merge into a cohesive whole but the vivid and energetic narrative is a winner nevertheless.